Testicular effect of Dr. Aladdin's seven keys herbal mixture in male Wistar rats

Background: Dr. Aladdin’s seven keys herbal mixture is widely used to relieve feverish conditions, and skin rashes especially in measles, chickenpox, viral infections, malaria, diarrhoea, ulcers, bacterial infections other conditions. Objective: The present study examined the testicular effect of Dr Aladdin's on male Wistar rats. Materials methods: A total 20 adult male. rats weighing between 140– 240 grams were divided into five groups (1-5) 4 each. Group 1 served as control, while Groups 2, 3, 4, 5 received via oral route 250 mg/kg, 500 1000 2000 mg/kg mixtures respectively for 28 days. At end drug administration, sacrificed blood samples collected determine serum levels testosterone follicle-stimulating hormone (FSH). testes harvested prepared semen analysis light microscopic study. Results: sperm count motility significantly reduced with marked alteration morphology a dose-dependent manner. hormonal assay showed decreased Histological findings also mild focal areas haemorrhage, infiltration inflammatory cells, moderate significant harmful seminiferous tubules/testicular functions, clumping cells Conclusion: This has shown cause severe effects testes, level parameters, thus may predispose addicted consumers infertility. consumption should strictly be based prescription qualified medical personnel.